Hyperprolactinaemia may affect sexual and reproductive functioning. However, recent studies suggest that increased prolactin levels may also have negative effects on cognition. We aimed to study whether the reduction in prolactin levels by cabergoline in patients with hyperprolactinaemia is followed by an improvement in cognitive tasks. We studied seven patients with hyperprolactinaemia caused by a prolactinoma that had an indication to start treatment with cabergoline. All patients were assessed twice (baseline and 6-12 months after cabergoline treatment) with a cognitive battery. Plasma prolactin levels were determined. We found a significant improvement in the speed of processing, working memory, visual learning and reasoning and problem-solving domains after cabergoline treatment. Improvements in speed of processing and reasoning and problem solving were greater in patients with baseline prolactin levels above the median. In summary, a reduction in prolactin levels by cabergoline in patients with hyperprolactinaemia is followed by an improvement in cognitive abilities. This finding suggests that prolactin may be involved in cognitive processes, although cabergoline could also have procognitive effects that are independent of prolactin changes. Further clinical trials are needed to confirm the potential cognitive-enhancement properties of cabergoline in patients with chronic hyperprolactinaemia.

中文翻译：

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卡麦角林治疗后分泌催乳素的垂体腺瘤患者认知能力的提高。

高催乳素血症可能会影响性和生殖功能。但是，最近的研究表明，催乳素水平升高也可能对认知产生负面影响。我们的目的是研究高催乳素血症患者中卡麦角林降低催乳素水平后，认知功能是否得到改善。我们研究了由催乳素瘤引起的高泌乳素血症的七名患者，这些患者有开始使用卡麦角林的适应症。使用认知电池对所有患者进行两次评估（基线和卡麦角林治疗后6-12个月）。确定血浆催乳素水平。我们发现卡麦角林治疗后的处理，工作记忆，视觉学习，推理和问题解决领域的速度有了显着提高。基线催乳素水平高于中位数的患者，处理，推理和问题解决速度的改善更大。总之，高催乳素血症患者卡麦角林降低催乳素水平后，认知能力得到改善。这一发现表明催乳激素可能参与了认知过程，尽管卡麦角林也可能具有与催乳素变化无关的认知作用。需要进一步的临床试验以确认卡麦角林在慢性高泌乳素血症患者中的潜在认知增强特性。这一发现表明催乳激素可能参与了认知过程，尽管卡麦角林也可能具有与催乳素变化无关的认知作用。需要进一步的临床试验以确认卡麦角林在慢性高泌乳素血症患者中的潜在认知增强特性。这一发现表明催乳激素可能参与了认知过程，尽管卡麦角林也可能具有与催乳素变化无关的认知作用。需要进一步的临床试验以确认卡麦角林在慢性高泌乳素血症患者中的潜在认知增强特性。