The diurnal profiles of pancreatic glucagon, insulin, pancreatic polypeptide (PP), and enteroglucagon were studied in five obese non-diabetic subjects (195 +/- 11 per cent of ideal body weight) and in six age matched controls. All the subjects were served with ordinary mixed meals five times during the day. The obese subjects were normoglycemic but hyperinsulinemic. Both groups showed rapid increases in PP to all meals, but the PP-response was significantly impaired in the obese group during the first part of the day. Normal subjects showed significant enteroglucagon responses to all meals, and had elevated levels throughout the day. In obese subjects, levels and responses were much lower at all times. Pancreatic glucagon profiles were similar. It is concluded that the possible role of abnormalities of PP and enteroglucagon secretion in the pathogenesis of human obesity deserves further study.

中文翻译：

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人体病态肥胖中胰腺多肽，胰高血糖素，肠道胰高血糖素和胰岛素的昼夜分布。

在五个肥胖的非糖尿病受试者（理想体重的195 +/- 11％）和六个年龄匹配的对照组中研究了胰高血糖素，胰岛素，胰多肽（PP）和肠胰高血糖素的昼夜分布。白天，所有受试者均接受五次普通混合餐。肥胖受试者血糖正常，但胰岛素过多。两组均显示所有进餐的PP迅速增加，但是在一天的第一部分中，肥胖组的PP反应明显受损。正常受试者对所有进餐表现出明显的胰高血糖素反应，并且全天水平升高。在肥胖的受试者中，水平和反应在任何时候都低得多。胰高血糖素的分布相似。