The extent of cyclic AMP (cAMP) mediated lipolysis in adipose tissue cells of man and several other animal species is regulated by the interplay of alpha- and beta-adrenoceptors modulating adenyl cyclase activity. Although the naturally-occurring catecholamines, and isoprenaline, are thought to act at the same pro-lipolytic beta-adrenoceptor antilipolytic agents, working through the alpha 2-adrenoceptor moiety of adenyl cyclase, appear to act at separate sites for: true alpha 2-agonists such as clonidine, for adenosine and for prostaglandins. Further, such antilipolytic agents are conspicuously more potent against lipolysis stimulated by methyl-isobutylxanthine (MIX) than against that stimulated by catecholamines. The nature of the dual character of adenyl cyclase remains to be elucidated. alpha 2 Adrenoceptor antagonists which promote lipolysis, and may possibly serve a therapeutic role in the treatment of obesity, may also provoke inappropriate insulin release which is contraindicated. Thus a problem in chemotherapy exists which may be resolved by new agents with differential tissue specificities. An example of this chemotherapeutic dilemma is possibly provided by the body weight accruing actions of tricyclic antidepressant compounds whose mechanism of action involves also (central) alpha 2-adrenoceptors.

中文翻译：

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对脂肪细胞的α2-肾上腺素受体有活性的药物在肥胖症治疗中的应用-一项重要的评估。

人类和其他几种动物的脂肪组织细胞中环AMP（cAMP）介导的脂解作用的程度受调节腺苷酸环化酶活性的α和β肾上腺素受体相互作用的调节。尽管人们认为天然存在的儿茶酚胺和异丙肾上腺素在相同的促脂解性β-肾上腺素受体抗脂解剂中起作用，但它们通过腺苷酸环化酶的α2-肾上腺素受体部分起作用，似乎在以下部位起作用：真正的α2-诸如可乐定的激动剂，腺苷和前列腺素的激动剂。此外，这种抗脂解剂对由甲基异丁基黄嘌呤（MIX）刺激的脂解明显比对儿茶酚胺刺激的解脂作用更强。腺苷酸环化酶的双重特征的性质尚待阐明。促进脂肪分解的alpha 2肾上腺素受体拮抗剂，并且可能在肥胖症的治疗中起治疗作用，还可能引起禁忌的不适当的胰岛素释放。因此，存在化学疗法中的问题，其可以通过具有不同组织特异性的新药剂来解决。这种化学疗法难题的一个例子可能是三环抗抑郁化合物的体重累积作用，其作用机理还涉及（中央）α2-肾上腺素受体。