The study was designed to evaluate whether the correlation occurring in simple obesity between insulin resistance and peripheral hyperinsulinemia corresponds to a relationship between insulin resistance and insulin overproduction by the pancreas. In addition, the study investigated the relation existing in simple obesity between insulin resistance and insulin metabolism. For these purposes, we measured and correlated: (1) insulin sensitivity, estimated by glucose disappearance rate from plasma after intravenous insulin injection; (2) insulin secretion by the pancreas, estimated by fasting C-peptide levels in peripheral blood; (3) insulin metabolism, estimated by means of C-peptide: insulin molar ratio in peripheral blood. Twenty-five subjects (20 females, five males) aged 21 to 59 years were studied. All were obese and had a normal glucose tolerance. Glucose disappearance rate from plasma after i.v. insulin injection averaged 3.65 +/- 0.42 mg/dl/min (mean +/- s.e.m.). Fasting C-peptide was 0.90 +/- 0.09 nmol/l. Fasting C-peptide: insulin molar ratio averaged 5.94 +/- 0.48. Negative correlations were found between glucose disappearance rates after i.v. insulin injection, ie, insulin sensitivity, and fasting concentrations of both insulin (r = -0.806, P less than 0.001) and C-peptide (r = -0.525, P less than 0.01). A positive relationship was found between glucose disappearance rate from plasma after i.v. insulin injection and fasting C-peptide: insulin molar ratio, ie, insulin metabolism (r = 0.707, P less than 0.001). We conclude that in simple obesity insulin overproduction by the pancreas is negatively related to insulin resistance, and insulin resistance and impaired insulin metabolism are strictly related phenomena.

中文翻译：

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单纯性肥胖患者胰岛素抵抗，胰岛素分泌与胰岛素代谢的关系。

该研究旨在评估在单纯性肥胖症中胰岛素抵抗与周围高胰岛素血症之间发生的相关性是否对应于胰岛素抵抗与胰腺胰岛素过度产生之间的关系。此外，该研究还探讨了单纯性肥胖中胰岛素抵抗与胰岛素代谢之间的关系。为此，我们测量并建立了相关性：（1）胰岛素敏感性，通过静脉注射胰岛素后血浆葡萄糖的消失率来估计；（2）胰腺的胰岛素分泌，通过空腹C肽水平评估。（3）胰岛素代谢，通过外周血中的C肽：胰岛素摩尔比来估算。研究对象为25名年龄在21至59岁之间的受试者（20名女性，5名男性）。所有的人都肥胖并且葡萄糖耐量正常。静脉注射胰岛素后血浆中葡萄糖的消失率平均为3.65 +/- 0.42 mg / dl / min（平均+/- sem）。空腹C肽为0.90 +/- 0.09nmol / l。空腹C肽：胰岛素摩尔比平均为5.94 +/- 0.48。静脉注射胰岛素后葡萄糖消失率（即胰岛素敏感性）与胰岛素（r = -0.806，P小于0.001）和C肽（r = -0.525，P小于0.01）的空腹浓度之间存在负相关关系。 。在静脉注射胰岛素后血浆葡萄糖消失率与空腹C肽：胰岛素摩尔比即胰岛素代谢之间存在正相关关系（r = 0.707，P小于0.001）。我们得出的结论是，在单纯性肥胖症中，胰腺胰岛素过度产生与胰岛素抵抗呈负相关，