Since increased opiate production in obesity has been reported, the effects of naloxone in obese subjects were studied in order to ascertain whether endogenous opioid peptides play a role in the abundant insulin secretion of obesity. The results obtained showed that intravenous administration of naloxone considerably reduced insulin of obese subjects to a mixed meal, whereas it did not modify the blood insulin response to arginine or glucose infusion. Glucagon secretion to ingestion of a mixed meal and to arginine infusion was not modified by the opioid receptor blocking agent. This study seems to indicate that hyperproduction of endogenous opioid peptides in obesity increases insulin secretion stimulated by food intake, whereas it does not appreciably affect insulin production stimulated by circulating glucose or aminoacids.

中文翻译：

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内源性阿片类药物可能参与人类肥胖症的β细胞高反应性。

由于已经报道了在肥胖中增加的鸦片生产，因此研究了纳洛酮在肥胖受试者中的作用，以确定内源性阿片肽是否在肥胖的大量胰岛素分泌中起作用。获得的结果表明，纳洛酮的静脉内给药可显着降低肥胖受试者混合餐的胰岛素，而不会改变血液对精氨酸或葡萄糖输注的胰岛素反应。摄取阿片类食物和摄取精氨酸的胰高血糖素分泌没有被阿片受体阻断剂改变。这项研究似乎表明，肥胖症中内源性阿片肽的过度生产会增加食物摄入刺激的胰岛素分泌，而不会显着影响循环葡萄糖或氨基酸刺激的胰岛素生产。