Growth retardation is a major feature of chronic kidney disease (CKD) of onset in infants or children and is associated with increased morbidity and mortality. Several factors have been shown to play a causal role in the growth impairment of CKD. All these factors interfere with growth by disturbing the normal physiology of the growth plate of long bones. To facilitate the understanding of the pathogenesis of growth impairment in CKD, this review discusses cellular and molecular alterations of the growth plate during uremia, including structural and dynamic changes of chondrocytes, alterations in their process of maturation and hypertrophy, and disturbances in the growth hormone signaling pathway.

中文翻译：

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慢性肾脏疾病中的生长板改变。

生长迟缓是婴儿或儿童中慢性肾脏疾病（CKD）发作的主要特征，并与发病率和死亡率增加相关。已经显示出几种因素在CKD的生长损伤中起因果作用。所有这些因素都会干扰长骨生长板的正常生理，从而影响生长。为便于了解CKD生长障碍的发病机理，本综述讨论了尿毒症期间生长板的细胞和分子变化，包括软骨细胞的结构和动态变化，成熟和肥大过程的变化以及生长激素的紊乱。信号通路。