Lymphocytes, such as T cells, B cells, and innate lymphoid cells (ILCs), play central roles in regulating immune responses. Retinoic acids (RAs) are vitamin A metabolites, produced and metabolized by certain tissue cells and myeloid cells in a tissue-specific manner. It has been established that RAs induce gut-homing receptors on T cells, B cells, and ILCs. A mounting body of evidence indicates that RAs exert far-reaching effects on functional differentiation and fate of these lymphocytes. For example, RAs promote effector T cell maintenance, generation of induced gut-homing regulatory and effector T cell subsets, antibody production by B cells, and functional maturation of ILCs. Key functions of RAs in regulating major groups of innate and adaptive lymphocytes are highlighted in this article.

中文翻译：

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RAR-视黄酸轴对先天性和适应性淋巴细胞的控制

淋巴细胞，如 T 细胞、B 细胞和先天淋巴细胞 (ILC)，在调节免疫反应中发挥核心作用。视黄酸 (RA) 是维生素 A 代谢物，由某些组织细胞和骨髓细胞以组织特异性方式产生和代谢。已经确定 RA 在 T 细胞、B 细胞和 ILC 上诱导肠道归巢受体。越来越多的证据表明 RA 对这些淋巴细胞的功能分化和命运产生深远的影响。例如，RA 促进效应 T 细胞维持、诱导肠道归巢调节和效应 T 细胞亚群的产生、B 细胞产生抗体以及 ILC 的功能成熟。本文重点介绍了 RA 在调节主要先天性和适应性淋巴细胞群中的关键功能。