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Animal-type melanoma: dog or wolf? A review of the literature and a case report
Expert Reviews in Molecular Medicine ( IF 4.5 ) Pub Date : 2018-09-12 , DOI: 10.1017/erm.2018.4
Luigia Stefania Stucci 1 , Raffaele Palmirotta 1 , Domenica Lovero 1 , Erica Silvestris 1 , Paola Cafforio 1 , Claudia Felici 1 , Annalisa Todisco 1 , Eleonora Nacchiero 2 , Federica Pezzuto 3 , Marco Tucci 1 , Franco Silvestris 1
Affiliation  

The human animal type melanoma (ATM) is a rare subtype of melanoma characterised by the proliferation of pigmented dermal epithelioid and spindled melanocytes. However, this variant of melanoma is still lacking a precise nosography definition and classification for the difficulty to be distinguished from other more common melanocytic lesions, as well as for its peculiar biological behaviour. On the other hand, the contribution of scientific literature to this issue is fragmented and limited to the description of very few cases. Starting from the presentation of a case with abnormally aggressive clinical features, here we revisit the current knowledge on ATM from its dermatologic patterns, epidemiology, demography and histopathology to the clinical management. Peculiar accuracy has also been reserved to several histopathologic criteria, which are critical for the differential diagnosis from other melanocytic diseases in junction with molecular data deriving from recent cytogenetic and mutational characterisation of this tumour.

中文翻译:

动物型黑色素瘤:狗还是狼?文献回顾及病例报告

人类动物型黑色素瘤 (ATM) 是一种罕见的黑色素瘤亚型,其特征是有色素的真皮上皮样细胞和梭形黑色素细胞的增殖。然而,由于难以与其他更常见的黑色素细胞病变区分开来,以及其特殊的生物学行为,这种黑色素瘤的变体仍然缺乏精确的 nosography 定义和分类。另一方面,科学文献对这个问题的贡献是零散的,仅限于对极少数案例的描述。从一个具有异常侵袭性临床特征的病例的介绍开始,我们在这里重新审视当前关于 ATM 的知识,从其皮肤病学模式、流行病学、人口学和组织病理学到临床管理。一些组织病理学标准也保留了特殊的准确性,
更新日期:2018-09-12
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