The purpose of this study was to establish interobserver reproducibility of Young’s modulus (YM) derived from ultrasound shear wave elastography (US-SWE) in the normal prostate and correlate it with multiparametric magnetic resonance imaging (mpMRI) tissue characteristics. Twenty men being screened for prostate cancer underwent same-day US-SWE (10 done by two blinded, newly-trained observers) and mpMRI followed by 12-core biopsy. Bland–Altman plots established limits of agreement for YM. Quantitative data from the peripheral zone (PZ) and the transitional zone (TZ) for YM, apparent diffusion coefficient (ADC, mm2/s from diffusion-weighted MRI), and Ktrans (volume transfer coefficient, min−1), Ve (extravascular-extracellular space, %), Kep (rate constant, /min), and initial area under the gadolinium concentration curve (IAUGC60, mmol/L/s) from dynamic contrast–enhanced MRI were obtained for slice-matched prostate sextants. Interobserver intraclass correlation coefficients were fair to good for individual regions (PZ = 0.57, TZ = 0.65) and for whole gland 0.67, (increasing to 0.81 when corrected for systematic observer bias). In the PZ, there were weak negative correlations between YM and ADC (p = 0.008), and Ve (p = 0.01) and a weak positive correlation with Kep (p = 0.003). No significant intermodality correlations were seen in the TZ. Transrectal prostate US-SWE done without controlling manually applied probe pressure has fair/good interobserver reproducibility in inexperienced observers with potential to improve this to excellent by standardization of probe contact pressure. Within the PZ, increase in tissue stiffness is associated with reduced extracellular water (decreased ADC) and space (reduced Ve).

中文翻译：

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正常前列腺的超声剪切波弹性成像：观察者间的再现性以及与功能磁共振组织特征的比较


本研究的目的是确定正常前列腺中超声剪切波弹性成像 (US-SWE) 杨氏模量 (YM) 的观察者间再现性，并将其与多参数磁共振成像 (mpMRI) 组织特征相关联。 20 名接受前列腺癌筛查的男性在同一天接受了 US-SWE（其中 10 名男性由两名盲人、新培训的观察者完成）和 mpMRI，随后进行了 12 芯活检。布兰德-奥特曼图确定了 YM 的协议限制。来自外围区 (PZ) 和过渡区 (TZ) 的 YM、表观扩散系数（ADC，来自扩散加权 MRI 的 mm2/s）和 Ktrans（体积转移系数，min−1）、Ve（血管外）的定量数据-从动态对比增强 MRI 中获得切片匹配前列腺六分仪的细胞外间隙，%）、Kep（速率常数，/min）和钆浓度曲线下初始面积（IAUGC60，mmol/L/s）。各个区域的观察者组内相关系数为一般至良好（PZ = 0.57，TZ = 0.65），整个腺体为 0.67（校正系统观察者偏差后增加至 0.81）。在 PZ 中，YM 与 ADC (p = 0.008) 和 Ve (p = 0.01) 之间存在弱负相关，与 Kep (p = 0.003) 之间存在弱正相关。在 TZ 中没有发现显着的多式联运相关性。在没有控制手动施加的探头压力的情况下完成的经直肠前列腺 US-SWE 对于缺乏经验的观察者具有公平/良好的观察者间再现性，并且有可能通过探头接触压力的标准化将其改进为优秀。在 PZ 内，组织硬度的增加与细胞外水（ADC 减少）和空间（Ve 减少）减少有关。