The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family cytokines emerged before the adaptive immune response. These cytokines elicit diverse host defense mechanisms, especially from epithelial cells, during various infections. IL-10 family cytokines are essential for maintaining the integrity and homeostasis of tissue epithelial layers. Members of this family can promote innate immune responses from tissue epithelia to limit the damage caused by viral and bacterial infections. These cytokines can also facilitate the tissue-healing process in injuries caused by infection or inflammation. Finally, IL-10 itself can repress proinflammatory responses and limit unnecessary tissue disruptions caused by inflammation. Thus, IL-10 family cytokines have indispensable functions in many infectious and inflammatory diseases.

中文翻译：

---

IL-10家族细胞因子在炎症和疾病中的调节和功能。

IL-10细胞因子家族由九个成员组成：IL-10，IL-19，IL-20，IL-22，IL-24，IL-26，以及与亲缘关系更远的IL-28A，IL-28B和IL-29。从进化上讲，IL-10家族的细胞因子在适应性免疫应答之前出现。这些细胞因子在各种感染过程中引发多种宿主防御机制，尤其是上皮细胞的防御机制。IL-10家族细胞因子对于维持组织上皮层的完整性和体内平衡至关重要。该家族的成员可以促进组织上皮的先天免疫反应，以限制由病毒和细菌感染引起的损害。这些细胞因子还可以促进感染或炎症引起的损伤中的组织愈合过程。最后，IL-10本身可以抑制促炎反应并限制炎症引起的不必要的组织破坏。从而，