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Kinetic analysis of the sodium gating current in the squid giant axon.
Proceedings of the Royal Society B: Biological Sciences ( IF 4.7 ) Pub Date : 1990-06-22 , DOI: 10.1098/rspb.1990.0045
R D Keynes 1 , N G Greeff , I C Forster
Affiliation  

A critical study has been made of the characteristics of the kinetic components of the sodium gating current in the squid giant axon, of which not less than five can be resolved. In addition to the principal fast component Ig2, there are two components of appreciable size that relax at an intermediate rate, Ig3 alpha and Ig 3 beta. Ig3 alpha has a fast rise, and is present over the whole range of negative test potentials. Ig3 beta is absent below -40 mV, exhibits a delayed onset and disappears on inactivation of the sodium system. There are also two smaller components, Ig1 and Ig4, with very fast and much slower relaxation time constants, respectively.

中文翻译:

鱿鱼巨型轴突中钠门控电流的动力学分析。

已经对鱿鱼巨型轴突中钠门控电流的动力学成分的特性进行了严格的研究,其中不少于五个可以被解决。除了主要的快速成分Ig2外,还有两个以中等速率松弛的可观大小的成分,即Ig3 alpha和Ig 3 beta。Ig3 alpha具有快速上升的趋势,并且存在于整个阴性测试电位范围内。Ig3 beta在-40 mV以下不存在,表现出延迟的发作,并在钠系统失活时消失。还有两个较小的分量,Ig1和Ig4,分别具有非常快和非常慢的弛豫时间常数。
更新日期:2019-11-01
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