Since its inception just over a half century ago, the field of biomaterials has seen a consistent growth with a steady introduction of new ideas and productive branches. This review describes where we have been, the state of the art today, and where we might be in 10 or 20 years. Herein, we highlight some of the latest advancements in biomaterials that aim to control biological responses and ultimately heal. This new generation of biomaterials includes surface modification of materials to overcome nonspecific protein adsorption in vivo, precision immobilization of signaling groups on surfaces, development of synthetic materials with controlled properties for drug and cell carriers, biologically inspired materials that mimic natural processes, and design of sophisticated three-dimensional (3-D) architectures to produce well-defined patterns for diagnostics, e.g., biological microelectromechanical systems (bioMEMs), and tissue engineering.

中文翻译：

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生物材料：我们去过的地方和要去的地方。

自半个多世纪以来创立以来，生物材料领域一直在持续增长，不断引入新的想法和生产分支。这篇评论描述了我们去过的地方，当今的技术水平以及未来十年或二十年后的发展趋势。在此，我们重点介绍了生物材料的最新进展，旨在控制生物反应并最终治愈。新一代生物材料包括材料的表面修饰，以克服体内非特异性蛋白质的吸附；将信号基团精确固定在表面上；开发对药物和细胞载体具有可控特性的合成材料；模仿自然过程的受生物启发的材料；