Soy infant formulas are widely used, but few studies have evaluated long-term safety or examined specific forms of toxicity, such as to the endocrine or immune systems. This review focuses on newer experimental studies of the effects on estrogen activity, immune function, and thyroid economy of genistein and daidzein, two isoflavones in soy infant formula, and existing human studies of soy formula use. In order to judge the likelihood that an endpoint seen in laboratory studies might occur in soy-fed infants, we examined the doses and the resulting serum or plasma concentrations from the laboratory studies and compared them with doses and concentrations seen in soy-fed infants. We also summarized the estimates of the potency of the isoflavone compounds relative to estradiol. Given the scarcity and inconsistency of existing human data and the substantial laboratory evidence of hormonal and other activity at doses relevant to the soy-fed infant, we conclude that more clinical and epidemiological study is warranted.

中文翻译：

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大豆婴儿配方食品中的异黄酮：婴儿内分泌和其他活性证据的综述。

大豆婴儿配方奶粉被广泛使用，但很少有研究评估长期安全性或检查特定形式的毒性，例如对内分泌或免疫系统的毒性。这篇综述着重于染料木黄酮和大豆黄酮，大豆婴儿配方食品中的两种异黄酮对雌激素活性，免疫功能和甲状腺经济的影响的最新实验研究，以及现有的人类对大豆配方食品使用的研究。为了判断在实验室研究中观察到的终点可能发生在大豆喂养婴儿中，我们检查了剂量以及实验室研究得出的血清或血浆浓度，并将它们与在大豆喂养婴儿中观察到的剂量和浓度进行了比较。我们还总结了异黄酮化合物相对于雌二醇的效价估计。