The Class 2 alpha-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22, IL-24 (Mda-7), and IL-26, interferons (IFN-alpha, -beta, -epsilon, -kappa, -omega, -delta, -tau, and -gamma) and interferon-like molecules (limitin, IL-28A, IL-28B, and IL-29). The interaction of these cytokines with their specific receptor molecules initiates a broad and varied array of signals that induce cellular antiviral states, modulate inflammatory responses, inhibit or stimulate cell growth, produce or inhibit apoptosis, and affect many immune mechanisms. The information derived from crystal structures and molecular evolution has led to progress in the analysis of the molecular mechanisms initiating their biological activities. These cytokines have significant roles in a variety of pathophysiological processes as well as in regulation of the immune system. Further investigation of these critical intercellular signaling molecules will provide important information to enable these proteins to be used more extensively in therapy for a variety of diseases.

中文翻译：

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白介素10及相关的细胞因子和受体。

2类α螺旋细胞因子由白介素10（IL-10），IL-19，IL-20，IL-22，IL-24（Mda-7）和IL-26干扰素（IFN-α， -β，-ε，-κ，-ω，-δ，-tau和-γ）和类似干扰素的分子（极限蛋白，IL-28A，IL-28B和IL-29）。这些细胞因子与其特异性受体分子的相互作用引发了广泛多样的信号，这些信号诱导细胞抗病毒状态，调节炎症反应，抑制或刺激细胞生长，产生或抑制细胞凋亡并影响许多免疫机制。来自晶体结构和分子进化的信息已导致分析开始其生物学活性的分子机制的进展。这些细胞因子在各种病理生理过程以及免疫系统的调节中具有重要作用。对这些关键的细胞间信号分子的进一步研究将提供重要的信息，以使这些蛋白质能够更广泛地用于各种疾病的治疗中。