Ena/VASP proteins are a conserved family of actin regulatory proteins made up of EVH1, EVH2 domains, and a proline-rich central region. They have been implicated in actin-based processes such as fibroblast migration, axon guidance, and T cell polarization and are important for the actin-based motility of the intracellular pathogen Listeria monocytogenes. Mechanistically, these proteins associate with barbed ends of actin filaments and antagonize filament capping by capping protein (CapZ). In addition, they reduce the density of Arp2/3-dependent actin filament branches and bind Profilin at sites of actin polymerization. Vertebrate Ena/VASP proteins are substrates for PKA/PKG serine/threonine kinases. Phosphorylation by these kinases appears to modulate Ena/VASP function within cells, although the mechanism underlying this regulation remains to be determined.

中文翻译：

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Ena / VASP蛋白：肌动蛋白细胞骨架和细胞迁移的调节剂。

Ena / VASP蛋白是保守的肌动蛋白调节蛋白家族，由EVH1，EVH2域和富含脯氨酸的中央区域组成。它们与基于肌动蛋白的过程有关，例如成纤维细胞迁移，轴突引导和T细胞极化，对细胞内病原体单核细胞增生李斯特菌的基于肌动蛋白的运动很重要。从机理上讲，这些蛋白质与肌动蛋白丝的带刺末端缔合，并通过加帽蛋白（CapZ）拮抗丝盖。此外，它们降低了依赖Arp2 / 3的肌动蛋白丝分支的密度，并在肌动蛋白聚合位点结合了Profilin。脊椎动物Ena / VASP蛋白是PKA / PKG丝氨酸/苏氨酸激酶的底物。这些激酶的磷酸化作用似乎可以调节细胞内的Ena / VASP功能，