The Notch signaling pathway is known to govern various aspects of tissue differentiation during embryonic development by mediating local cell-cell interactions that often control cell fate. The conserved components that underlie Notch signaling have been isolated in vertebrates, leading to a biochemical delineation of a core Notch signaling pathway and functional studies of this pathway during embryogenesis. Herein we highlight recent progress in determining how Notch signaling contributes to the development of the vertebrate embryo. We first discuss the role of Notch in the process of segmentation where rapid changes have been shown to occur in both the spatial and temporal aspects of Notch signaling, which are critical for segmental patterning. Indeed, the role of Notch in segmentation re-emphasizes a recurring question in Notch biology: how are the components involved in Notch signaling regulated to ensure their dynamic properties? Second, we address this question by discussing recent work on the biochemical mechanisms that potentially regulate Notch signaling during segmentation, including those that act on the receptors, ligands, and signal transduction apparatus.

中文翻译：

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在体发生过程中调节Notch信号传导。

已知，Notch信号通路通过介导通常控制细胞命运的局部细胞间相互作用，在胚胎发育过程中控制组织分化的各个方面。Notch信号基础的保守成分已在脊椎动物中分离出来，从而导致了核心Notch信号途径的生化描述以及在胚胎发生过程中对该途径的功能研究。本文中，我们重点介绍了在确定Notch信号如何促进脊椎动物胚胎发育中的最新进展。我们首先讨论Notch在分割过程中的作用，在分割过程中，Notch信号的空间和时间方面都显示出快速变化，这对于分割模式至关重要。实际上，Notch在细分中的作用再次强调了Notch生物学中一个反复出现的问题：如何调节Notch信号传导中涉及的成分以确保其动态特性？第二，我们通过讨论有关生化机制的最新研究来解决这个问题，该生化机制可能在分割过程中调节Notch信号传导，包括那些作用于受体，配体和信号转导装置的机制。