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Archeal DNA replication: eukaryal proteins in a bacterial context.
Annual Review of Microbiology ( IF 8.5 ) Pub Date : 2003-10-07 , DOI: 10.1146/annurev.micro.57.030502.090709
Beatrice Grabowski 1 , Zvi Kelman
Affiliation  

Genome sequences of a number of archaea have revealed an apparent paradox in the phylogenies of the bacteria, archaea, and eukarya, as well as an intriguing set of problems to be resolved in the study of DNA replication. The archaea, long thought to be bacteria, are not only different enough to merit their own domain but also appear to be an interesting mosaic of bacterial, eukaryal, and unique features. Most archaeal proteins participating in DNA replication are more similar in sequence to those found in eukarya than to analogous replication proteins in bacteria. However, archaea have only a subset of the eukaryal replication machinery, apparently needing fewer polypeptides and structurally simpler complexes. The archaeal replication apparatus also contains features not found in other organisms owing, in part, to the broad range of environmental conditions, some extreme, in which members of this domain thrive. In this review the current knowledge of the mechanisms governing DNA replication in archaea is summarized and the similarities and differences of those of bacteria and eukarya are highlighted.

中文翻译:

原始DNA复制:在细菌环境中的真核蛋白质。

许多古细菌的基因组序列已在细菌,古细菌和真核生物的系统发育中揭示了一个明显的悖论,以及在DNA复制研究中需要解决的一系列令人着迷的问题。长期以来一直被认为是细菌的古细菌,不仅具有不同的优势,可以发挥自己的功能,而且似乎是细菌,真核生物和独特特征的有趣马赛克。与细菌中类似的复制蛋白相比,大多数参与DNA复制的古细菌蛋白的序列与真核生物中的蛋白更相似。然而,古细菌只有真核复制机制的一个子集,显然需要更少的多肽和结构上更简单的复合物。古细菌复制装置还具有其他生物中未发现的特征,部分原因是 广泛的环境条件(在某些极端情况下),使该领域的成员蓬勃发展。在这篇综述中,总结了在古细菌中控制DNA复制的机制的当前知识,并突出了细菌和真核生物的异同。
更新日期:2019-11-01
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