Vaccinia virus (VV), the virus smallpox vaccine, replicates in the cytoplasm of infected cells. The intracellular movement of this large virus would be inefficient without specific transport mechanisms; therefore, VV uses microtubules for movement during both entry and egress. In addition, the dissemination of virus from infected cells to adjacent cells is promoted by the polymerization of actin beneath cell surface virions to drive virus particles away from the cell. Last, the roles of different VV particles in virus movement within and between hosts are discussed.

中文翻译：

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牛痘病毒运动。

天花疫苗Vaccinia病毒（VV）在感染细胞的细胞质中复制。如果没有特定的转运机制，这种大病毒的细胞内移动将是无效的。因此，VV在进入和排出过程中都使用微管进行运动。另外，通过在细胞表面病毒体下的肌动蛋白的聚合来促进病毒从感染细胞向邻近细胞的传播，从而驱使病毒颗粒离开细胞。最后，讨论了不同VV粒子在宿主内部和宿主之间的病毒移动中的作用。