Bacteriophages have developed an impressive array of ingenious mechanisms to modify bacterial host RNA polymerase to make it serve viral needs. In this review we summarize the current knowledge about two types of host RNA polymerase modifications induced by double-stranded DNA phages: covalent modifications and modifications through RNA polymerase-binding proteins. We interpret the biochemical and genetic data within the framework of a structure-function model of bacterial RNA polymerase and viral biology.

中文翻译：

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噬菌体诱导的宿主RNA聚合酶修饰。

噬菌体已经开发出一系列令人印象深刻的巧妙机制，可以修饰细菌宿主RNA聚合酶以使其满足病毒需求。在这篇综述中，我们总结了有关双链DNA噬菌体诱导的两种宿主RNA聚合酶修饰的当前知识：共价修饰和通过RNA聚合酶结合蛋白的修饰。我们在细菌RNA聚合酶和病毒生物学的结构功能模型的框架内解释生化和遗传数据。