Genetic screens in Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio clarified the logic of metazoan development by revealing critical unitary steps and pathways to embryogenesis. Can genetic screens similarly organize medicine? We here examine human diseases that resemble mutations in Danio rerio, the zebrafish, the one vertebrate species for which large-scale genetic screens have been performed and extensively analyzed. Zebrafish mutations faithfully phenocopy many human disorders. Each mutation, once cloned, provides candidate genes and pathways for evaluation in the human. The collection of mutations in their entirety potentially provides a medical taxonomy, one based in developmental biology and genetics.

中文翻译：

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从斑马鱼到人类：模块化医学模型。

果蝇，秀丽隐杆线虫和达尼奥雷里奥的遗传筛选通过揭示关键的单一步骤和胚胎发生途径，阐明了后生动物的发育逻辑。基因筛查可以类似地组织药物吗？我们在这里检查类似于斑马鱼Danio rerio中的突变的人类疾病，斑马鱼是已经对其进行大规模遗传筛选并广泛分析的一种脊椎动物。斑马鱼突变忠实地复制了许多人类疾病。每种突变一旦被克隆，就会提供候选基因和途径供人类评估。突变的整体收集可能提供医学分类学，一种基于发育生物学和遗传学的分类学。