Gene finding in genetically complex diseases has been difficult as a result of many factors that have diagnostic and methodologic considerations. For bipolar disorder and schizophrenia, numerous family, twin, and adoption studies have identified a strong genetic component to these behavioral psychiatric disorders. Despite difficulties that include diagnostic differences between sample populations and the lack of statistical significance in many individual studies, several promising patterns have emerged, suggesting that true susceptibility loci for schizophrenia and bipolar disorder may have been identified. In this review, the genetic epidemiology of these disorders is covered as well as linkage findings on chromosomes 4, 12, 13, 18, 21, and 22 in bipolar disorder and on chromosomes 1, 6, 8, 10, 13, 15, and 22 in schizophrenia. The sequencing of the human genome and identification of numerous single nucleotide polymorphisms (SNP) should substantially enhance the ability of investigators to identify disease-causing genes in these areas of the genome.

中文翻译：

---

精神疾病的连锁分析：新出现的情况。

由于许多具有诊断和方法学考虑的因素，在遗传复杂疾病中寻找基因一直很困难。对于双相情感障碍和精神分裂症，许多家庭，双胞胎和收养研究已经确定了这些行为性精神疾病的强大遗传成分。尽管困难包括样本人群之间的诊断差异以及许多个体研究中缺乏统计学意义，但仍出现了一些有前途的模式，这表明精神分裂症和双相情感障碍的真正易感基因位点已经确定。在这篇综述中，涵盖了这些疾病的遗传流行病学以及双相情感障碍中染色体4、12、13、18、21、22和染色体1、6、8、10、13、15和15上的连锁发现。 22在精神分裂症。