Spindle microtubules interact with mitotic chromosomes, binding to their kinetochores to generate forces that are important for accurate chromosome segregation. Motor enzymes localized both at kinetochores and spindle poles help to form the biologically significant attachments between spindle fibers and their cargo, but microtubule-associated proteins without motor activity contribute to these junctions in important ways. This review examines the molecules necessary for chromosome-microtubule interaction in a range of well-studied organisms, using biological diversity to identify the factors that are essential for organized chromosome movement. We conclude that microtubule dynamics and the proteins that control them are likely to be more important for mitosis than the current enthusiasm for motor enzymes would suggest.

中文翻译：

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有丝分裂期间的染色体-微管相互作用。

纺锤体微管与有丝分裂染色体相互作用，与它们的动植物结合，产生对于精确染色体分离非常重要的力。位于动植物和纺锤体极的运动酶有助于在纺锤体纤维和它们的货物之间形成生物学上重要的附着，但是没有运动活性的微管相关蛋白以重要方式促进了这些连接。这篇综述检查了一系列经过充分研究的生物体中染色体-微管相互作用所必需的分子，并利用生物多样性来确定对于组织的染色体运动必不可少的因素。我们得出的结论是，微管动力学和控制微管动力学的蛋白质可能比当前对运动酶的热情所暗示的对有丝分裂更为重要。