Dietary selenium intake is regarded as an important factor in determining optimal health and susceptibility to disease. Therefore, it is critical to understand the interaction between selenium intake and molecular events at the genetic and cellular level. This article addresses two facets of this interaction. The first facet is how genomics is contributing to understanding the molecular mechanisms by which selenium affects cell function through selenoproteins and downstream targets of Se supply in other metabolic pathways. The contribution of transgenic animals in this field is emphasized, and the more recent studies using transcriptomics are discussed. The second facet is the extent to which single nucleotide polymorphisms (SNPs) in genes encoding selenoproteins and components of the selenoprotein synthetic machinery affect individual dietary requirements for optimal health. The state of knowledge of known functional SNPs in selenoprotein genes is presented, and a strategy for future studies is discussed.

中文翻译：

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营养基因组学和硒：基因表达模式，生理靶标和遗传学。

饮食中硒的摄入被认为是确定最佳健康状况和疾病易感性的重要因素。因此，在遗传和细胞水平上了解硒摄入与分子事件之间的相互作用至关重要。本文介绍了这种交互的两个方面。第一个方面是基因组学如何帮助理解硒通过硒蛋白以及其他代谢途径中硒供应的下游靶标影响细胞功能的分子机制。强调了转基因动物在该领域的贡献，并讨论了使用转录组学的最新研究。第二个方面是编码硒蛋白和硒蛋白合成机制成分的基因中的单核苷酸多态性（SNP）影响个体饮食需求以达到最佳健康程度的程度。介绍了已知的硒蛋白基因中已知功能性SNP的知识状态，并讨论了未来研究的策略。