A model for the formation of the genetic code is presented where protein synthesis is directed initially by tRNA dimers. Proteins that are resistant to degradation and efficient RNA-binders protect the RNAs. Replication becomes elongational producing poly-tRNAs from which the mRNAs and ribosomes are derived. Attributions are successively fixed to tRNAs paired through the perfect palindromic anticodons, with the same bases at the extremities (5'ANA: UNU 3'; GNG: CNC; principal dinucleotides, pDiN). The 5' degeneracy is then developed. The first pairs to be encoded correspond to the hydropathy correlation outliers (Gly-CC: Pro-GG and Ser-GA: Ser-CU) and to the sector of homogeneous pDiN, composed by two pyrimidines or two purines. These amino acids are preferred in the N-ends of proteins, stabilizers of proteins against catabolism and strong RNA-binders. The next pairs complete the sector of homogeneous pDiN (Asp, Glu-UC: Leu-AG and Asn, Lys-UU: Phe-AA). This set of nine amino acids forms the protein cores with the predominant aperiodic conformation. Next enter the pairs with mixed pDiN (one purine and one pyrimidine), the RY attributions composing the protein N-ends and the YR attributions the C-ends. The last pair contains the main punctuation signs (Ile, Met, iMet-AU: Tyr, Stop-UA). The model indicates that genetic information emerged during the process of formation of the coding/decoding system and that genes were defined by the proteins. Stable proteins constructed the nucleoprotein system by binding to the RNAs that produced them. In this circular rationale, genes are memories in a metabolic system for production of proteins that stabilize it. The simplicity and the highly deterministic character of the process suggest that the Last Universal Common Ancestor populations could be composed, in early stages, of lineages bearing similar genetic codes.

中文翻译：

---

用于形成遗传密码的自我参照模型。

提出了一个形成遗传密码的模型，其中蛋白质合成最初由 tRNA 二聚体指导。抗降解的蛋白质和高效的 RNA 结合剂可以保护 RNA。复制变得伸长，产生多聚 tRNA，mRNA 和核糖体来源于该多聚 tRNA。属性依次固定到通过完美回文反密码子配对的 tRNA，在四肢具有相同的碱基（5'ANA：UNU 3'；GNG：CNC；主要二核苷酸，pDiN）。然后发展5'简并。要编码的第一对对应于亲水性相关异常值（Gly-CC：Pro-GG 和 Ser-GA：Ser-CU）和由两个嘧啶或两个嘌呤组成的均质 pDiN 扇区。这些氨基酸优先出现在蛋白质的 N 端，抗分解代谢的蛋白质稳定剂和强 RNA 结合剂。接下来的配对完成了均质 pDiN 的部分（Asp、Glu-UC：Leu-AG 和 Asn、Lys-UU：Phe-AA）。这组九个氨基酸形成了具有主要非周期性构象的蛋白质核心。接下来输入具有混合 pDiN（一个嘌呤和一个嘧啶）的配对，RY 属性构成蛋白质 N 端，YR 属性构成 C 端。最后一对包含主要标点符号（Ile、Met、iMet-AU：Tyr、Stop-UA）。该模型表明遗传信息是在编码/解码系统形成过程中出现的，基因是由蛋白质定义的。稳定的蛋白质通过与产生它们的 RNA 结合来构建核蛋白系统。在这个循环理由中，基因是代谢系统中的记忆，用于生产稳定它的蛋白质。该过程的简单性和高度确定性特征表明，在早期阶段，最后的普遍共同祖先种群可以由具有相似遗传密码的谱系组成。