Study of the influence of different concentrations of glucose, as carbon source, and magnesium, as chemical additive, on production by the Streptomyces sp. US80 strain of the three antifungal molecules (irumamycin, X-14952 B and 17-hydroxy-venturicidin A) showed that the highest antifungal activity was obtained at 5 g/L and 3.5 mM for glucose and magnesium, respectively. Environmental factors for maximum antifungal activity production are: temperature of growth 30 degrees C, pH 7, incubation time 72 h and agitation rate of 200 rpm. To further enhance the production of the three antifungal compounds, which possess a real potential application in the agriculture domain, and to explore the possibility of obtaining other active molecules from the Streptomyces sp. US80, we investigated the effect of the addition of heat-killed fungi to the culture media. Biochemical, microbiological and spectroscopic studies of the cultures of the Streptomyces sp. US80 strain in absence (control) and in presence of heat-killed fungus cells indicate an increase of 70% in the production of the three antifungal molecules, compared to the control culture.

中文翻译：

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陆生链霉菌US80菌株的抗真菌活性由热灭活真菌诱导。

研究不同浓度的葡萄糖（作为碳源）和镁（作为化学添加剂）对链霉菌属菌种生产的影响。三种抗真菌分子（irumamycin，X-14952 B和17-羟基-venturicidin A）的US80菌株显示，分别对葡萄糖和镁分别以5 g / L和3.5 mM获得最高的抗真菌活性。产生最大的抗真菌活性的环境因素是：生长温度30摄氏度，pH 7，孵育时间72小时，搅拌速度200 rpm。为了进一步提高三种抗真菌化合物的生产，这三种化合物在农业领域具有真正的潜在应用，并探索从链霉菌中获得其他活性分子的可能性。US80，我们研究了向培养基中添加热灭活真菌的效果。链霉菌属菌种培养物的生化，微生物学和光谱学研究。与对照培养相比，在不存在（对照）和存在热灭活真菌细胞的情况下，US80菌株表明三种抗真菌分子的产量增加了70％。