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Random perturbations of spiking activity in a pair of coupled neurons.
Theory in Biosciences ( IF 1.3 ) Pub Date : 2008-05-01 , DOI: 10.1007/s12064-008-0039-7
Boris Gutkin 1 , Jürgen Jost , Henry C Tuckwell
Affiliation  

We examine the effects of stochastic input currents on the firing behaviour of two coupled Type 1 or Type 2 neurons. In Hodgkin-Huxley model neurons with standard parameters, which are Type 2, in the bistable regime, synaptic transmission can initiate oscillatory joint spiking, but white noise can terminate it. In Type 1 cells (models), typified by a quadratic integrate and fire model, synaptic coupling can cause oscillatory behaviour in excitatory cells, but Gaussian white noise can again terminate it. We locally determine an approximate basin of attraction, [see text] of the periodic orbit and explain the firing behaviour in terms of the effects of noise on the probability of escape of trajectories from [see text].

中文翻译:

一对耦合神经元中尖峰活动的随机扰动。

我们研究了随机输入电流对两个耦合的 1 型或 2 型神经元的放电行为的影响。在具有标准参数的 Hodgkin-Huxley 模型神经元中,即类型 2,在双稳态机制中,突触传递可以启动振荡关节尖峰,但白噪声可以终止它。在以二次积分和激发模型为代表的 1 类细胞(模型)中,突触耦合会导致兴奋性细胞的振荡行为,但高斯白噪声可以再次终止它。我们在本地确定了一个近似的吸引力盆地,[参见文本] 周期轨道,并根据噪声对 [参见文本] 中轨迹逃逸概率的影响来解释发射行为。
更新日期:2019-11-01
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