The 5-HT(3) and GABA(A) receptors are members of the Cys-loop family of neurotransmitter-gated ion channels that also include receptors for glycine and acetylcholine. The 5-HT(3) and acetylcholine receptors (cationic ion channels) and the GABA(A) and glycine receptors (anionic ion channels) generally depolarize or hyperpolarize, respectively, the neuronal membrane. Within the amino-terminal extracellular region, all members of this family exhibit a similar architecture of ligand binding domains and a number of key residues are completely conserved. The molecular characterization of their ligand binding and gating characteristics has benefited from the existence of a large repertoire of individual subunits that contribute to the pentameric ion channel. Although differences do exist, advances in our knowledge of one member offers valuable insight into the family as a whole. Each member of the Cys-loop receptors (and all other multimeric ion channels) must face the same challenges: How to assemble individual subunits into an ion channel and which subunits to use? How are assembled receptors distinguished from those that are unassembled or misassembled, then exported from the endoplasmic reticulum and delivered to the cell surface? How are they targeted to, and anchored at synaptic and extrasynaptic sites? How and when are they to be removed from these sites to provide long-term regulation of neuronal activity? In this review, we summarize our current knowledge for the 5-HT(3) and GABA(A) receptors that have provided complementary information and helped us build an overall picture of how receptor biogenesis and trafficking occurs.

中文翻译：

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贩运5-HT（3）和GABA（A）受体（综述）。

5-HT（3）和GABA（A）受体是神经递质门控离子通道Cys环家族的成员，该通道还包括甘氨酸和乙酰胆碱的受体。5-HT（3）和乙酰胆碱受体（阳离子通道）以及GABA（A）和甘氨酸受体（阴离子通道）通常分别使神经元膜去极化或超极化。在氨基末端细胞外区域内，该家族的所有成员均表现出相似的配体结合域结构，并且许多关键残基被完全保守。它们的配体结合和门控特性的分子表征已受益于大量构成五聚体离子通道的单个亚基。尽管确实存在差异，我们对一名成员的了解的提高为整个家庭提供了宝贵的见识。半胱氨酸环受体的每个成员（以及所有其他多聚体离子通道）都必须面临相同的挑战：如何将单个亚基组装到离子通道中以及要使用哪些亚基？组装后的受体与未组装或未组装后从内质网输出并传递到细胞表面的受体有何区别？它们如何针对并固定在突触和突触外部位？如何以及何时将它们从这些部位去除，以提供对神经元活动的长期调节？在这篇评论中