This article gives an overview of the ethical issues in nutrigenomics research and personalized nutrition. The principles of research ethics, i.e., autonomy, beneficence, nonmalfeasance, and justice, are challenged by rapidly growing cross-border research activities utilizing existing and upcoming biobanks for studies of the interaction of genes with diet on risk of common diseases. We highlight the ethical issues, some unresolved, in international collaborative projects of which researchers should be aware. Personalized nutrition (tailoring diet on the basis of genotype) is one possible application of nutrigenomics research. However, until the scientific evidence concerning diet-gene interactions is much more robust, the provision of personalized dietary advice on the basis of specific genotype remains questionable. From the ethical and social perspective, nutrigenomics offers significant opportunities to improve public health by enhancing understanding of the mechanisms through which diet can be used to reduce the risk of common polygenic diseases.

中文翻译：

---

人类营养学的生物伦理学考虑。

本文概述了营养经济学研究和个性化营养中的伦理问题。研究伦理学的原则，即自治，善意，非渎职和正义，正受到迅速增长的跨界研究活动的挑战，这些活动利用现有和即将到来的生物库来研究基因与饮食之间的相互作用，以探讨常见疾病的风险。我们在研究人员应该意识到的国际合作项目中着重强调一些尚未解决的伦理问题。个性化营养（根据基因型量身定制饮食）是营养学研究的一种可能应用。然而，直到有关饮食与基因相互作用的科学证据变得更加可靠为止，基于特定基因型提供个性化饮食建议仍存在疑问。