The yeast Saccharomyces cerevisiae is invaluable for understanding fundamental cellular processes and disease states of relevance to higher eukaryotes. Plant viruses are intracellular parasites that take advantage of resources of the host cell, and a simple eukaryotic cell, such as yeast, can provide all or most of the functions for successful plant virus replication. Thus, yeast has been used as a model to unravel the interactions of plant viruses with their hosts. Indeed, genome-wide and proteomics studies using yeast as a model host with bromoviruses and tombusviruses have facilitated the identification of replication-associated factors that affect host-virus interactions, virus pathology, virus evolution, and host range. Many of the host genes that affect the replication of the two viruses, which belong to two dissimilar virus families, are distinct, suggesting that plant viruses have developed different ways to utilize the resources of host cells. In addition, a surprisingly large number of yeast genes have been shown to affect RNA-RNA recombination in tombusviruses; this opens an opportunity to study the role of the host in virus evolution. The knowledge gained about host-virus interactions likely will lead to the development of new antiviral methods and applications in biotechnology and nanotechnology, as well as new insights into cellular functions of individual genes and the basic biology of the host cell.

中文翻译：

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酵母作为模型宿主探索植物病毒与宿主的相互作用。

酵母酿酒酵母对于了解基本的细胞过程和与高等真核生物有关的疾病状态具有不可估量的价值。植物病毒是利用宿主细胞资源的细胞内寄生虫，简单的真核细胞（如酵母菌）可以提供所有或大部分功能，以成功复制植物病毒。因此，酵母已被用作解开植物病毒与其宿主相互作用的模型。确实，使用酵母作为溴代病毒和线粒体病毒的模型宿主，在全基因组和蛋白质组学方面的研究已经促进了与复制相关的因素的鉴定，这些因素影响宿主与病毒的相互作用，病毒病理学，病毒进化和宿主范围。许多影响两种病毒复制的宿主基因属于两个不同的病毒家族，它们是截然不同的，表明植物病毒已经开发出利用宿主细胞资源的不同方法。另外，已显示出惊人的大量酵母基因会影响线粒体病毒中的RNA-RNA重组。这为研究宿主在病毒进化中的作用提供了机会。有关宿主-病毒相互作用的知识可能将导致新的抗病毒方法及其在生物技术和纳米技术中的应用，以及对单个基因的细胞功能和宿主细胞基本生物学的新见解。这为研究宿主在病毒进化中的作用提供了机会。有关宿主-病毒相互作用的知识可能将导致新的抗病毒方法及其在生物技术和纳米技术中的应用，以及对单个基因的细胞功能和宿主细胞基本生物学的新见解。这为研究宿主在病毒进化中的作用提供了机会。有关宿主-病毒相互作用的知识可能将导致新的抗病毒方法及其在生物技术和纳米技术中的应用，以及对单个基因的细胞功能和宿主细胞基本生物学的新见解。