Secondary lymphoid organs develop during embryogenesis or in the first few weeks after birth according to a highly coordinated series of interactions between newly emerging hematopoietic cells and immature mesenchymal or stromal cells. These interactions are orchestrated by homeostatic chemokines, cytokines, and growth factors that attract hematopoietic cells to sites of future lymphoid organ development and promote their survival and differentiation. In turn, lymphotoxin-expressing hematopoietic cells trigger the differentiation of stromal and endothelial cells that make up the scaffolding of secondary lymphoid organs. Lymphotoxin signaling also maintains the expression of adhesion molecules and chemokines that govern the ultimate structure and function of secondary lymphoid organs. Here we describe the current paradigm of secondary lymphoid organ development and discuss the subtle differences in the timing, molecular interactions, and cell types involved in the development of each secondary lymphoid organ.

中文翻译：

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次级淋巴器官的发育。

根据新出现的造血细胞和未成熟的间充质或基质细胞之间高度协调的一系列相互作用，次级淋巴器官在胚胎发生期间或出生后的最初几周内发育。这些相互作用是由稳态趋化因子、细胞因子和生长因子精心策划的，这些因子将造血细胞吸引到未来淋巴器官发育的部位并促进它们的存活和分化。反过来，表达淋巴毒素的造血细胞会触发构成次级淋巴器官支架的基质细胞和内皮细胞的分化。Lymphotoxin 信号还维持粘附分子和趋化因子的表达，这些分子和趋化因子控制次级淋巴器官的最终结构和功能。