The aim of the present study is to synthesize some novel ecofriendly fungicides and bactericides of indole-2,3-dione derivatives, having important pharmacodynamic significance. The ligands used in the present account are derived by the condensation of 1,3-dihydro-3-[2-(phenyl)-2-oxoethylidene]-2H-indol-2- one, 1,3-dihydro-3-[2-(4-nitrophenyl)-2-oxoethylidene]-2H-indol-2-one and 1,3-dihydro-3-[2-(4-nitro-3-methylphenyl)- 2-oxoethylidene]-2H-indol-2-one with hydrazinecarboxamide and hydrazinecarbothioamide. These imines, on interaction with diorganosilicon(IV) chlorides, yield complexes having Si-O or Si-S and Si<--N bonds. The structure of these compounds have been elucidated by elemental microanalyses and spectral [(UV), (IR), (1)H, (13)C and (29)Si NMR)] studies which unerringly point to a trigonal bipyramidal and octahedral geometries for unimolar and bimolar reactions, respectively. The potency of the synthesized compounds have been assessed by growth inhibiting potential of the complexes against variety of fungal and bacterial strains and male albino rats. The results of these biological studies have been compared with the standard fungicide, Bavistin. The studies demonstrate that, 1,3-dihydro-3-[2-(4-nitrophenyl)-2-oxoethylidene]-2H-indol-2-onehydrazincarbothioamide and its diphenylsilicon(IV) complexes have comparable antimicrobial activity and are less toxic to male albino rats than Bavistin.

中文翻译：

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吲哚-2,3-二酮衍生物的新型生物有效二有机硅 (IV) 复合物。

本研究的目的是合成一些具有重要药效学意义的吲哚-2,3-二酮衍生物的新型环保杀菌剂和杀菌剂。本帐户中使用的配体通过 1,3-二氢-3-[2-(苯基)-2-氧代亚乙基]-2H-indol-2-one, 1,3-dihydro-3-[ 2-(4-nitrophenyl)-2-oxoethylidene]-2H-indol-2-one 和 1,3-dihydro-3-[2-(4-nitro-3-methylphenyl)-2-oxoethylidene]-2H-indol -2-一种与肼甲酰胺和肼甲硫酰胺。这些亚胺与二有机硅 (IV) 氯化物相互作用，产生具有 Si-O 或 Si-S 和 Si<--N 键的配合物。这些化合物的结构已通过元素微量分析和光谱 [(UV), (IR), (1)H, (13)C 和 (29)Si NMR)] 研究分别准确地指出了单摩尔和双摩尔反应的三角双锥和八面体几何形状。已通过复合物对各种真菌和细菌菌株以及雄性白化大鼠的生长抑制潜力来评估合成化合物的效力。这些生物学研究的结果已与标准杀菌剂 Bavistin 进行了比较。研究表明，1,3-二氢-3-[2-(4-硝基苯基)-2-氧代亚乙基]-2H-indol-2-onehydrazincarbothioamide及其二苯基硅(IV)复合物具有相当的抗菌活性，对人体的毒性较小。雄性白化大鼠比 Bavistin 强。已通过复合物对各种真菌和细菌菌株以及雄性白化大鼠的生长抑制潜力来评估合成化合物的效力。这些生物学研究的结果已与标准杀菌剂 Bavistin 进行了比较。研究表明，1,3-二氢-3-[2-(4-硝基苯基)-2-氧代亚乙基]-2H-indol-2-onehydrazincarbothioamide及其二苯基硅(IV)复合物具有相当的抗菌活性，对人体的毒性较小。雄性白化大鼠比 Bavistin 强。已通过复合物对各种真菌和细菌菌株以及雄性白化大鼠的生长抑制潜力来评估合成化合物的效力。这些生物学研究的结果已与标准杀菌剂 Bavistin 进行了比较。研究表明，1,3-二氢-3-[2-(4-硝基苯基)-2-氧代亚乙基]-2H-indol-2-onehydrazincarbothioamide及其二苯基硅(IV)复合物具有相当的抗菌活性，对人体的毒性较小。雄性白化大鼠比 Bavistin 强。