Fourteen to eighteen membered tetraazamacrocyclic ligands N(4)TTD(1)-N(4)TTD(4) have been synthesized by the condensation of aliphatic diamines. H(2)N-(CH(2))(y)-NH(2) (y = 2 or 3) and dicarboxylic acids, HOOC-(CH(2))(x)-COOH (x = 1 or 2) in the presence of condensing reagents dicyclohexylcarbodiimide (DCHC) and 4-dimethylaminopyridine (DMAP). On reduction these macrocyclic ligands give N(4)TTD(5)-N(4)TTD(8), which form complexes with manganese(II) acetate. The new products with octahedral geometry have been characterized by elemental analyses, molecular weight determinations, magnetic moment and spectral studies viz., infrared, electronic, mass and X-ray. On the basis of the spectral studies the binding sites are proposed as the nitrogen atom of the macrocycles. The formulation of the complexes as [Mn(CH(3)COO)(2)(N(4)TTD(n))] (where n = 1 - 8) has been established on the basis of chemical composition. To assess the growth inhibiting potential of the ligands and their manganese (II) complexes biological screening have been undertaken. The testicular morphology, testicular sperm density, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trials and biochemical parameters of reproductive organs with ligands and their corresponding complexes, in vivo have also been described in the this communication.

中文翻译：

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潜在的生物动力学四氮杂大环化合物及其锰配合物：抗雄激素、抗菌和 PDI 研究。

十四至十八元四氮杂大环配体 N(4)TTD(1)-N(4)TTD(4) 已通过脂肪族二胺的缩合合成。H(2)N-(CH(2))(y)-NH(2) (y = 2 or 3) 和二元羧酸，HOOC-(CH(2))(x)-COOH (x = 1 or 2 ) 在缩合试剂二环己基碳二亚胺 (DCHC) 和 4-二甲氨基吡啶 (DMAP) 的存在下。还原时这些大环配体得到 N(4)TTD(5)-N(4)TTD(8)，它与乙酸锰 (II) 形成复合物。八面体几何的新产品已通过元素分析、分子量测定、磁矩和光谱研究（即红外、电子、质量和 X 射线）进行表征。在光谱研究的基础上，结合位点被认为是大环的氮原子。[Mn(CH(3)COO)(2)(N(4)TTD(n))]（其中 n = 1 - 8）的配合物配方是根据化学成分确定的。为了评估配体及其锰 (II) 复合物的生长抑制潜力，已经进行了生物筛选。交配试验中的睾丸形态、睾丸精子密度、精子活力、附睾尾精子密度和生育力以及配体及其相应复合物在体内的生殖器官的生化参数也已在本通讯中进行了描述。