Antimicrobial resistance is a major public health crisis, eroding the discovery of antimicrobials and their application to clinical medicine. There is a general lack of knowledge of the importance of agricultural antimicrobial use as a factor in antimicrobial resistance even among experts in medicine and public health. This review focuses on agricultural antimicrobial drug use as a major driver of antimicrobial resistance worldwide for four reasons: It is the largest use of antimicrobials worldwide; much of the use of antimicrobials in agriculture results in subtherapeutic exposures of bacteria; drugs of every important clinical class are utilized in agriculture; and human populations are exposed to antimicrobial-resistant pathogens via consumption of animal products as well as through widespread release into the environment.

中文翻译：

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工业食用动物生产，抗菌素耐药性和人类健康。

抗菌素耐药性是主要的公共卫生危机，侵蚀了抗菌素的发现及其在临床医学中的应用。甚至在医学和公共卫生领域的专家中，普遍缺乏对农业抗菌素使用作为抗菌素耐药性因素的重要性的知识。这篇综述集中在农业抗菌药物的使用上，这是全世界抗菌素耐药性的主要驱动力，其原因有四个：农业中大量使用抗菌剂会导致细菌在亚治疗范围内暴露；在农业中使用各种重要临床类别的药物；而且人类通过食用动物产品以及广泛释放到环境中而暴露于抗药性病原体。