Probucol is a diphenolic compound with anti-oxidant and anti-inflammatory properties that reduces atherosclerosis and restenosis. Unfortunately, adverse effects on blood lipoproteins and cardiac electrophysiology have curtailed its use as a drug. Compounds related to probucol that have improved efficacy without the adverse effects offer promise as novel therapies of cardiovascular disease. Recent results suggest that these compounds may be used for the prevention of type 2 diabetes, a disease that is increasing in prevalence and importance world-wide. In this review, the molecular mechanisms underlying the beneficial activities of probucol and related compounds are described.

中文翻译：

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普罗布考和相关化合物的抗动脉粥样硬化和抗糖尿病特性。

普罗布考是一种具有抗氧化剂和抗炎特性的双酚类化合物，可减少动脉粥样硬化和再狭窄。不幸的是，对血液脂蛋白和心脏电生理学的不利影响已经限制了其用作药物。与普罗布考有关的具有改善的功效而没有副作用的化合物有望作为心血管疾病的新疗法。最近的结果表明，这些化合物可用于预防2型糖尿病，这种疾病在世界范围内的患病率和重要性都在增加。在这篇综述中，描述了普罗布考和相关化合物的有益活性的分子机制。