T cell cytoarchitecture differs dramatically depending on whether the cell is circulating within the bloodstream, migrating through tissues, or interacting with antigen-presenting cells. The transition between these states requires important signaling-dependent changes in actin cytoskeletal dynamics. Recently, analysis of actin-regulatory proteins associated with T cell activation has provided new insights into how T cells control actin dynamics in response to external stimuli and how actin facilitates downstream signaling events and effector functions. Among the actin-regulatory proteins that have been identified are nucleation-promoting factors such as WASp, WAVE2, and HS1; severing proteins such as cofilin; motor proteins such as myosin II; and linker proteins such as ezrin and moesin. We review the current literature on how signaling pathways leading from diverse cell surface receptors regulate the coordinated activity of these and other actin-regulatory proteins and how these proteins control T cell function.

中文翻译：

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肌动蛋白细胞骨架在T细胞活化中。

T细胞的细胞结构差异很大，这取决于细胞是在血液中循环，通过组织迁移还是与抗原呈递细胞相互作用。这些状态之间的转换需要肌动蛋白细胞骨架动力学中重要的信号依赖变化。最近，与T细胞活化相关的肌动蛋白调节蛋白的分析为T细胞如何响应外部刺激控制肌动蛋白动力学以及肌动蛋白如何促进下游信号传导事件和效应子功能提供了新见解。在已经鉴定出的肌动蛋白调节蛋白中，有成核促进因子，如WASp，WAVE2和HS1。切断蛋白，如cofilin；运动蛋白，例如肌球蛋白II；以及连接蛋白，例如ezrin和moesin。