T cells are critical mediators of the allergic airway inflammation seen in asthma. Pathogenic allergen-specific T cells are generated in regional lymph nodes and are then recruited into the airway by chemoattractants produced by the asthmatic lung. These recruited effector T cells and their products then mediate the cardinal features of asthma: airway eosinophilia, mucus hypersecretion, and airway hyperreactivity. There has been considerable progress in delineating the molecular mechanisms that control T cell trafficking into peripheral tissue, including the asthmatic lung. In this review, we summarize these advances and formulate them into a working model that proposes that T cell trafficking into and out of the allergic lung is controlled by several discrete regulatory pathways that involve the collaboration of innate and acquired immune cells.

中文翻译：

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过敏性哮喘中的 T 细胞贩运：来龙去脉。

T 细胞是哮喘中出现的过敏性气道炎症的关键介质。致病性过敏原特异性 T 细胞在区域淋巴结中产生，然后被哮喘肺产生的化学引诱物募集到气道中。这些募集的效应 T 细胞及其产物随后介导哮喘的主要特征：气道嗜酸性粒细胞增多、粘液分泌过多和气道高反应性。在描述控制 T 细胞转运到外周组织（包括哮喘肺）的分子机制方面取得了相当大的进展。在这篇综述中，我们总结了这些进展并将它们制定成一个工作模型，该模型提出 T 细胞进出过敏性肺是由几个独立的调节途径控制的，这些途径涉及先天性和获得性免疫细胞的协作。