Yeast cells sense the amount and quality of external nutrients through multiple interconnected signaling networks, which allow them to adjust their metabolism, transcriptional profile and developmental program to adapt readily and appropriately to changing nutritional states. We present our current understanding of the nutritional sensing networks yeast cells rely on for perceiving the nutritional landscape, with particular emphasis on those sensitive to carbon and nitrogen sources. We describe the means by which these networks inform the cell's decision among the different developmental programs available to them-growth, quiescence, filamentous development, or meiosis/sporulation. We conclude that the highly interconnected signaling networks provide the cell with a highly nuanced view of the environment and that the cell can interpret that information through a sophisticated calculus to achieve optimum responses to any nutritional condition.

中文翻译：

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酵母菌对营养物质的反应。

酵母细胞通过多个相互关联的信号网络感知外部营养素的数量和质量，这使它们能够调整其新陈代谢、转录谱和发育程序，以轻松、适当地适应不断变化的营养状态。我们介绍了我们目前对酵母细胞感知营养状况所依赖的营养传感网络的理解，特别强调对碳和氮源敏感的那些。我们描述了这些网络在它们可用的不同发育程序中告知细胞决定的方式——生长、静止、丝状发育或减数分裂/孢子形成。