Intra-uterine growth retardation (IUGR) is an abnormality of pregnancy. Neonates with IUGR weigh less than the 10th percentile for gestational age. The objective of the study was to identify the relationship between IUGR and the antioxidant status. Cord blood of 157 neonates with normal weight (control group) and 29 neonates with IUGR were included. The following parameters were determined and compared in the two groups: lipid peroxidation in the plasma, red blood cells and erythrocyte ghosts; protein and DNA damage; antioxidant enzyme activities (superoxide dismutase, catalase, glutathione peroxidase); the level of reduced glutathione; and the ferric reducing ability of the plasma. The level of lipid peroxidation was significantly higher in the IUGR group. The antioxidant enzyme activities and the levels of antioxidants were significantly lower in the IUGR group. Damage of proteins and DNA was slightly, but non-significantly, higher in the IUGR group. Neonates with IUGR seem to have significant deficiencies in antioxidant defence. IUGR is correlated with significant oxidative stress.

中文翻译：

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对子宫内发育迟缓的新生儿氧化应激指标的评估。

宫内发育迟缓（IUGR）是怀孕的异常现象。IUGR的新生儿体重小于胎龄的百分之十。该研究的目的是确定IUGR与抗氧化剂状态之间的关系。包括157例体重正常的新生儿（对照组）和29例IUGR的新生儿的脐血。在两组中确定并比较以下参数：血浆中脂质过氧化，红细胞和红细胞重影；蛋白质和DNA损伤；抗氧化酶活性（超氧化物歧化酶，过氧化氢酶，谷胱甘肽过氧化物酶）；还原型谷胱甘肽的水平；以及血浆的铁还原能力。IUGR组的脂质过氧化水平明显更高。IUGR组的抗氧化酶活性和抗氧化剂水平明显降低。在IUGR组中，蛋白质和DNA的损伤稍高，但无统计学意义。患有IUGR的新生儿似乎在抗氧化剂防御方面存在重大缺陷。IUGR与明显的氧化应激相关。