The dynamic range of a bacterial species' natural environment is reflected in the complexity of its systems that control cell cycle progression and its range of adaptive responses. We discuss the genetic network and integrated three-dimensional sensor/response systems that regulate the cell cycle and asymmetric cell division in the bacterium Caulobacter crescentus. The cell cycle control circuitry is tied closely to chromosome replication and morphogenesis by multiple feedback pathways from the modular functions that implement the cell cycle. The sophistication of the genetic regulatory circuits and the elegant integration of temporally controlled transcription and protein synthesis with spatially dynamic phosphosignaling and proteolysis pathways, and epigenetic regulatory mechanisms, form a remarkably robust living system.

中文翻译：

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杆状杆菌的系统生物学。

细菌物种自然环境的动态范围反映在其控制细胞周期进程及其适应性反应范围的系统的复杂性中。我们讨论了遗传网络和集成的三维传感器/响应系统，它们调节了新月形细菌中的细胞周期和不对称细胞分裂。细胞周期控制电路通过来自实现细胞周期的模块功能的多个反馈途径与染色体复制和形态发生紧密相关。遗传调控电路的复杂性以及时间控制的转录和蛋白质合成与空间动态磷信号和蛋白水解途径以及表观遗传调控机制的完美结合，形成了非常强大的生命系统。