In the tobacco hornworm, Manduca sexta, 5-hydroxytryptamine (5HT) acting at the level of the antennal lobes contributes significantly to changing the moth's responsiveness to olfactory stimuli. 5HT targets K(+) conductances in the cells, increasing the excitability of central olfactory neurons and their responsiveness to olfactory cues. Effects of 5HT modulation are apparent not only at the single cell level, but also in the activity patterns of populations of neurons that convey olfactory information from antennal lobes to higher centers of the brain. Evidence suggests that 5HT-induced changes in activity within neural circuits of the antennal lobes might also drive structural plasticity, providing the basis for longer-term changes in antennal lobe function.

中文翻译：

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蛾中枢嗅觉神经元的5-羟色胺调节。

在烟草天蛾中，在触角叶水平上起作用的5-羟色胺（5HT）在天蛾中，显着地改变了蛾对嗅觉刺激的响应。5HT靶向细胞中的K（+）电导，增加了中央嗅神经元的兴奋性及其对嗅觉提示的响应。5HT调节的作用不仅在单细胞水平上很明显，而且在将嗅觉信息从触角向大脑较高的中心传递的神经元群体的活动模式中也很明显。有证据表明，5HT诱导的触角神经回路内活动的变化也可能驱动结构可塑性，为触角叶功能的长期变化提供基础。