The ability of dendritic cells (DCs) to initiate and orchestrate immune responses is a consequence of their localization within tissues and their specialized capacity for mobilization. The migration of a given DC subset is typified by a restricted capacity for recirculation, contrasting markedly with T cells. Routes of DC migration into lymph nodes differ notably for distinct DC subsets. Here, we compare the distinct migratory patterns of plasmacytoid DCs (pDCs), CD8alpha(+) DCs, Langerhans cells, and conventional myeloid DCs and discuss how the highly regulated patterns of DC migration in vivo may affect their roles in immunity. Finally, to gain a more molecular appreciation of the specialized migratory properties of DCs, we review the signaling cascades that govern the process of DC migration.

中文翻译：

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树突状细胞亚群及其前体的迁移。

树突状细胞（DC）发起和协调免疫反应的能力是它们在组织中的定位及其动员的专门能力的结果。给定DC子集的迁移以有限的再循环能力为代表，与T细胞形成鲜明对比。DC迁移到淋巴结的途径对于不同的DC子集而言明显不同。在这里，我们比较了浆细胞样DC（pDC），CD8alpha（+）DC，Langerhans细胞和常规髓样DC的不同迁移模式，并讨论了DC体内迁移的高度调控模式如何影响其在免疫中的作用。最后，为了更深入地了解DC的特殊迁移特性，我们回顾了控制DC迁移过程的信号级联。