Large-conductance calcium and voltage-activated potassium channels, termed SLO-1 (or BK), are pivotal players in the regulation of cell excitability across the animal phyla. Furthermore, emerging evidence indicates that these channels are key mediators of a number of neuroactive drugs, including the most recent new anthelmintic, the cyclo-octadepsipeptide emodepside. Detailed reviews of the structure, function and pharmacology of BK channels have recently been provided (Salkoff et al. in Nat Rev Neurosci 7:921-931, 2006; Ghatta et al. in Pharmacol Ther 110:103-116, 2006) and therefore these aspects will only briefly be covered here. The purpose of this review is to discuss how SLO-1 channels might function as regulators of neural transmission and network activity. In particular, we focus on the role of SLO-1 in the regulation of Caenorhabditis elegans behaviour and highlight the role of this channel as an effector for pleiotropic actions of neuroactive drugs, including emodepside. On the premise that C. elegans is a 'model nematode' with respect to many aspects of neural function, the intention is that this might inform a broader understanding of the role of these channels in the nematodes and their potential as novel anthelmintic targets.

中文翻译：

---

SLO，SLO，快，快，慢：钙激活钾通道作为秀丽隐杆线虫行为的调节剂和驱虫药的目标。

大电导钙离子和电压激活的钾离子通道，称为 SLO-1（或 BK），是调节整个动物门细胞兴奋性的关键参与者。此外，新出现的证据表明，这些通道是许多神经活性药物的关键介质，包括最新的新型驱虫药环八肽依莫地肽。最近提供了对 BK 通道的结构、功能和药理学的详细评论（Salkoff 等人在 Nat Rev Neurosci 7:921-931, 2006 中；Ghatta 等人在 Pharmacol Ther 110:103-116, 2006 中），因此此处仅简要介绍这些方面。本综述的目的是讨论 SLO-1 通道如何作为神经传输和网络活动的调节器发挥作用。特别是，我们专注于 SLO-1 在调节秀丽隐杆线虫行为中的作用，并强调该通道作为神经活性药物（包括艾莫肽）多效作用的效应器的作用。就神经功能的许多方面而言，秀丽隐杆线虫是一种“模型线虫”，其目的是为了更广泛地了解这些通道在线虫中的作用及其作为新型驱虫目标的潜力。