Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) kinase kinase of the c-Jun N-terminal kinase (JNK) and p38 MAPK pathways. ASK1 is preferentially activated by various cytotoxic stressors and plays pivotal roles in a wide variety of cellular response to them. Recent analyses of ASK1 orthologs in Caenorhabditis elegans and Drosophila melanogaster have revealed that ASK1 is an evolutionarily conserved signaling intermediate in stress responses and appears to constitute a primitive but efficient defense system against stimuli harmful to organisms. Consistent with this notion, ASK1 has been shown to be required for the innate immune response, which is essential for host defense against a wide range of pathogens. In this review, we focus on the molecular mechanisms by which ASK1 functions in stress and immune responses and discuss the possible involvement of ASK1 in human diseases.

中文翻译：

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应激和免疫反应中的凋亡信号调节激酶1。

凋亡信号调节激酶1（ASK1）是c-Jun N端激酶（JNK）和p38 MAPK途径的促分裂原活化蛋白激酶（MAPK）激酶。ASK1被各种细胞毒性应激物优先激活，并在对它们的多种细胞反应中起关键作用。最近对秀丽隐杆线虫和果蝇果蝇ASK1直系同源物的分析表明，ASK1是应激反应中进化上保守的信号中间物，似乎构成了一种原始但有效的防御系统，可对抗有害生物。与此概念一致，已证明先天免疫应答需要ASK1，这对于宿主防御多种病原体至关重要。在这篇评论中