Epigenetics is a new development in complex non-Mendelian disease, which may not only uncover etiologic and pathogenic mechanisms but may also provide the basis for the development of medications that would target the primary epigenetic causes of such diseases. Such epigenetic drugs would be novel, potentially possessing substantially higher therapeutic potential and a much lower rate of adverse effects in comparison to current symptomatic treatments. A collection of epigenetic drugs already exist at various stages of development and, although their effectiveness has yet to be maximized, they show great promise in the treatment of cancer, psychiatric disorders, and other complex diseases. Here we present a review of the epigenetic theory of complex disease and an evaluation of current epigenetic therapies, as well as predictions of the future directions in this expanding field.

中文翻译：

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表观遗传学和复杂疾病：从病因学到新疗法。

表观遗传学是复杂的非孟德尔疾病的新发展，它不仅可以揭示病因和致病机理，而且还可以为开发针对此类疾病的主要表观遗传病因的药物提供基础。这样的表观遗传药物将是新颖的，与当前的对症治疗相比，具有潜在更高的治疗潜力和更低的不良反应率。表观遗传学药物的集合已经处于发展的各个阶段，尽管其有效性尚未得到最大发挥，但它们在治疗癌症，精神疾病和其他复杂疾病方面显示出巨大的希望。在这里，我们对复杂疾病的表观遗传学理论进行了综述，并对当前的表观遗传学治疗方法进行了评估，