The chemokine system coordinates leukocyte migration in immunity and inflammation and is implicated in the pathogenesis of many human diseases. Although several successful strategies have been identified to develop drugs targeting chemokines and their receptors, this has not yet resulted in many new therapeutics. This is likely due to a complexity of the chemokine system, which was not initially appreciated, that is characterized by redundancy, pleiotropy, and differences among species. Nevertheless, our understanding of chemokine biology is continuing to grow and several promising drugs are currently being tested in late-stage clinical trials. In this review, we examine the role of chemokines in health and diseases and discuss strategies to target the chemokine system.

中文翻译：

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趋化因子及其受体：免疫和炎症的药物靶标。

趋化因子系统协调白细胞在免疫和炎症中的迁移，并与许多人类疾病的发病机制有关。尽管已经确定了几种成功的策略来开发靶向趋化因子及其受体的药物，但这尚未产生许多新的疗法。这可能是由于趋化因子系统的复杂性，最初并没有意识到这一点，其特征是冗余，多效性和物种之间的差异。尽管如此，我们对趋化因子生物学的理解仍在继续增长，并且几种有希望的药物目前正在后期临床试验中进行测试。在这篇综述中，我们研究了趋化因子在健康和疾病中的作用，并讨论了针对趋化因子系统的策略。