Coxiella burnetii is a macrophage-tropic, Gram-negative organism, which causes acute Q fever infection in humans. This zoonotic infection causes illness ranging from asymptomatic seroconversion to severe and protracted disease featuring hepatitis and pneumonia. Interactions between C. burnetii lipopolysaccharide (LPS) and host Toll-like receptors (TLR)-2 and -4 have been implicated in pathogen recognition, phagocytosis and signaling responses. Nonconservative single nucleotide polymorphisms in the coding regions of TLR-2 (Arg677Trp and Arg753Gln) and TLR-4 (Asp299Gly) have been found to correlate with mycobacterial infections and Gram-negative sepsis respectively. Associations between the TLR-2 and -4 polymorphisms, illness characteristics and immune response parameters were examined in subjects with acute Q fever (n=85) and comparison subjects with viral infections (n=162). No correlation was demonstrated between these polymorphisms and susceptibility to Q fever, illness severity or illness course.

中文翻译：

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Toll样受体2和-4的多态性与急性Q发热的疾病表现无关。

伯氏柯氏杆菌是嗜巨噬细胞，革兰氏阴性生物，可引起人类急性Q发热。这种人畜共患的感染引起的疾病范围从无症状的血清转化到以肝炎和肺炎为特征的严重且持久的疾病。伯氏梭菌脂多糖（LPS）与宿主Toll样受体（TLR）-2和-4之间的相互作用已被认为与病原体识别，吞噬作用和信号传导反应有关。已发现TLR-2（Arg677Trp和Arg753Gln）和TLR-4（Asp299Gly）的编码区中的非保守单核苷酸多态性分别与分枝杆菌感染和革兰氏阴性败血症相关。TLR-2和-4多态性之间的关联，在急性Q发热的受试者（n = 85）和有病毒感染的比较受试者（n = 162）中检查疾病特征和免疫反应参数。这些多态性与对Q发热，疾病严重程度或病程的敏感性之间没有相关性。