Cytosolic Ca2+ signals are crucial for the control of fluid and enzyme secretion from exocrine glands. The highly polarized exocrine acinar cells have evolved sophisticated and complex Ca2+ signaling mechanisms that exercise precise control of the secretory events occurring across the apical plasma membrane bordering the gland lumen. Ca2+ stores in the endoplasmic reticulum, the secretory granules, the lysosomes, and the endosomes all play important roles in the generation of the local apical Ca2+ spikes that switch on Cl(-) channels in the apical plasma membrane as well as exocytotic export of enzymes. The mitochondria are crucial not only for ATP generation but also for the physiologically important subcellular compartmentalization of the cytosolic Ca2+ signals.

中文翻译：

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外分泌腺细胞中的极化钙信号。

细胞溶质 Ca2+ 信号对于控制外分泌腺的液体和酶分泌至关重要。高度极化的外分泌腺泡细胞已经进化出复杂而复杂的 Ca2+ 信号传导机制，可以精确控制发生在与腺腔相邻的顶端质膜上的分泌事件。内质网、分泌颗粒、溶酶体和内体中的 Ca2+ 储存在局部顶端 Ca2+ 尖峰的产生中起着重要作用，这些尖峰会打开顶端质膜中的 Cl(-) 通道以及酶的胞吐输出. 线粒体不仅对于 ATP 的产生至关重要，而且对于细胞溶质 Ca2+ 信号的生理上重要的亚细胞区室化也至关重要。