Cell surface mucins are large transmembrane glycoproteins involved in diverse functions ranging from shielding the airway epithelium against pathogenic infection to regulating cellular signaling and transcription. Although hampered by the relatively recent characterization of cell surface mucins and the difficulties inherent in working with molecules of their size, numerous studies have placed the tethered mucins in the thick of normal and diseased lung physiology. This review focuses on the three best-characterized cell surface mucins expressed in the respiratory tract: MUC1, MUC4, and MUC16.

中文翻译：

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细胞表面（栓系）粘蛋白的结构和功能。

细胞表面粘蛋白是大型跨膜糖蛋白，涉及多种功能，范围从保护气道上皮免受病原体感染到调节细胞信号传导和转录。尽管受到细胞表面粘蛋白相对较新的表征和处理其大小的分子固有的困难的困扰，但许多研究已将拴系粘蛋白置于正常和患病的肺部生理中。这篇评论集中在呼吸道中表达的三种最典型的细胞表面粘蛋白：MUC1，MUC4和MUC16。