Bcl-2 family members are important regulators of cell survival and cell death. Researchers have focused mainly on mitochondria, where both proapoptotic and antiapoptotic family members function to regulate the release of cytochrome c and other mediators of apoptosis. However, as reviewed here, Bcl-2 family members also operate on another front, the endoplasmic reticulum (ER), to both positively and negatively regulate the release of Ca2+. There is abundant evidence that Ca2+ signals trigger apoptosis in response to a wide variety of agents and conditions. Conversely, Ca2+ signals can also mediate cell survival. Recent findings indicate that Bcl-2 interacts with inositol 1,4,5-trisphosphate (IP3) receptor Ca2+ channels on the ER, regulating their opening in response to IP3- and thus inhibiting IP3-mediated Ca2+ signals that induce apoptosis while enhancing Ca2+ signals that support cell survival.

中文翻译：

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Bcl-2蛋白家族成员：钙信号传导在细胞存活和凋亡中的多功能调节剂。

Bcl-2家族成员是细胞存活和细胞死亡的重要调节剂。研究人员主要集中在线粒体上，线粒体中促凋亡和抗凋亡家族成员均起着调节细胞色素c释放和其他凋亡介质的作用。但是，如本文所述，Bcl-2家族成员也在另一个方面起作用，即内质网（ER），以正向和负向调节Ca2 +的释放。有大量证据表明，Ca2 +信号可响应多种因素和条件触发细胞凋亡。相反，Ca2 +信号也可以介导细胞存活。最近的发现表明，Bcl-2与ER上的肌醇1,4,5-三磷酸（IP3）受体Ca2 +通道相互作用，