The expression of many genes involved in xenobiotic/drug metabolism and transport is regulated by at least three nuclear receptors or xenosensors: aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), and pregnane X receptor (PXR). These receptors establish crosstalk with other nuclear receptors or transcription factors controlling signaling pathways that regulate the homeostasis of bile acids, lipids, glucose, inflammation, vitamins, hormones, and others. These crosstalks are expected to modify profoundly our vision of xenobiotic/drug disposition and toxicity. They provide molecular mechanisms to explain how physiopathological stimuli affect xenobiotic/drug disposition, and how xenobiotics/drugs may affect physiological functions and generate toxic responses. In addition, the possibility that xenosensors may control other signaling pathways opens the way to new pharmacological opportunities.

中文翻译：

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控制异种生物新陈代谢和运输的核受体缠结：串扰和后果。

涉及异种生物/药物代谢和运输的许多基因的表达受至少三种核受体或异种传感器的调节：芳烃受体（AhR），组成型雄烷受体（CAR）和孕烷X受体（PXR）。这些受体与其他核受体或控制信号通路的转录因子建立串扰，所述信号通路调节胆汁酸，脂质，葡萄糖，炎症，维生素，激素等的稳态。预计这些串扰将深刻改变我们对异种/药物处置和毒性的看法。它们提供了分子机制来解释生理病理刺激如何影响异种生物/药物的处置，以及异种生物/药物如何影响生理功能并产生毒性反应。此外，